How to Open a Dispensary in missouri


Do you want to learn how to open a dispensary in Missouri? On this page, we’ll keep you up to date on the most recent news and information about starting a cannabis business in Missouri. This includes valuable insights into what the state is likely to face in the future.

Missouri is the 21st state to legalize marijuana for recreational use. On November 8th, 2022 election day, voters in Missouri chose in support of a ballot measure, Amendment 3, that would legalize the possession, cultivation, and legalized retail sale of cannabis for people aged 21 and older. 

On March 31st, 2022, Missouri’s House of Representatives approved a bill that will legalize, tax and regulate recreational marijuana. The Cannabis Freedom Act passed the House Public Safety Committee 5-4 with amendments. 

On May 8th, 2022, Legal Missouri 2022 submitted more than 385,000 signatures to the state. To submit the subject to a vote, they will need 171,592 of those submissions to be validated. On August 9th, the secretary of state of Missouri announced that the question of legalizing marijuana for adult use would be on the ballot for November 8th. On September 9th, a state court dismissed the legal challenge filed by anti-legalization groups. Here is the whole 38-page proposal for an amendment of article XIV to legalize cannabis in Missouri.

Since October 1st, 2022, the campaign known as Legal Missouri 2022 has received approximately 700,000 dollars in significant campaign donations. The majority of the contributions are coming from businesses in the state that deal with medicinal marijuana. These businesses would get priority when it comes to obtaining licenses to sell cannabis for adult use. 

On November 10th, 2022, the Missouri Department of Health and Human Services (DHHS) announced proposed adult-use market draft regulations and started a public comment period. Missourians are encouraged to submit public comments during the next two weeks to assist officials finalize the rules. 

On December 8th, 2022, cannabis legalization in Missouri took effect, allowing adults over the age of 21 to possess up to 3 ounces without facing criminal penalties, and allowing existing medical marijuana dispensaries to begin applying for comprehensive licenses. All 191 of Missouri’s currently operational medicinal dispensaries are eligible to apply to become recreational retailers. Licensed businesses can start selling recreational marijuana to adults on February 8th, 2023. 

Since the DHSS began accepting applications on December 8th, the majority of Missouri’s medical cannabis operators have applied for a new license to service the adult-use market. In total, 318 of the state’s 322 medicinal cannabis licensees have submitted applications for comprehensive licenses to the DHSS. Within 60 days, the DHSS must decide whether or not to approve the applications. 

The Opportunity Size

Cannabis for recreational use represents a massive business opportunity with tremendous growth potential. The 2020 Marijuana Business Factbook says that by 2024, the MMJ market in Missouri will be worth between $525 million and $650 million. In another study by Grand View Research, Inc., the Missouri medical cannabis market is expected to be worth $102.4 million in 2026 and grow at a CAGR of 22.0 percent over the next few years.

Local Cannabis Laws & Restrictions

When considering opening a cannabis business in Missouri, one of the critical factors to consider is location. Under Amendment 2, local governments may not stop people from setting up marijuana businesses in their area, but they can set up rules like operating hours and fines. Marijuana facilities cannot be located within 1,000 feet of a school, daycare center, or church unless they are allowed by the neighborhood.

Missouri has local jurisdictions that have passed laws and regulations that make it legal for people to have small amounts of marijuana. Columbia, Kansas City, Maplewood, St. Louis, and Webster Groves are cities that have decriminalized marijuana through either voter initiatives or city council laws.

Medical Marijuana

On November 6, 2018, Missourians voted to legalize the use of medical marijuana for qualified patients who have a doctor’s certificate. Amendment 2 passed with 65.5 percent of the vote.

On December 6, 2018, the law came into effect. During late 2019 and early 2020, the state began giving licenses to medical cannabis dispensaries, labs, growers, and producers. Missouri was able to get its medical marijuana program up and running within 23 months instead of the national average of 29 months.

With the permission of a doctor, a person who has been diagnosed with Cancer, Epilepsy, Glaucoma, or another covered medical condition may be able to get medical marijuana. 

The number of medicinal marijuana patients enrolled in Missouri continues to rise on a steady basis. According to state records, there were more than 160,000 qualifying patients, 3,000 caregivers, and 300 facilities by the end of 2021.

Medical Marijuana Program Opportunities

The Department of Health and Senior Services (DHSS) in Missouri is in charge of making sure that the market structure is set up to meet the legal demand for medical marijuana as well as regulating and controlling medical marijuana facilities.

There are six types of business licenses for medical marijuana businesses in Missouri: dispensary license, cultivation license, infused product manufacturing license, laboratory testing license, transportation license, and seed to sale license.

Dispensary facility annual fee costs $11,099.35 and renewal fee costs $3,329.81 according to the fees submitted July 1, 2022 – June 30, 2023.

Medical Marijuana Facility Application 

Only transportation, facility agent and seed-to-sale applications are presently available. These will be accepted by DHSS indefinitely. Transportation applications will be filed via the Missouri Medical Marijuana Registry Portal, a secure, online system. For seed-to-sale applications and instructions on how to apply, go to their online application page. You can also check Facility FAQs for more details about licensing/certification, security measures, and more.

Recreational Use Legalization

On August 27, 2021, Legal Missouri 22 filed an initiative to legalize recreational marijuana. On December 1, 2021, the campaign for Legal Missouri 2022 officially began. 

Voters in Missouri approved a ballot measure to make marijuana use for recreational purposes legal on November 8, 2022. What will be accomplished as a result of the Legal Missouri 2022 program is as follows:

  • Three ounces of cannabis may be bought by those over 21.
  • With a registration card, people may cultivate six flowering, six immature, and six cloned marijuana plants.
  • The Department of Health and Senior Services will oversee and license cannabis companies.
  • At least 144 microbusiness licenses will be awarded by lottery and preference will be given to low-income applicants and individuals whose lives have been disproportionately affected by drug prohibition.
  • Current medical marijuana retailers will also be the first to begin serving adult customers with dual licenses.
  • The new license holders for each type will be chosen at random through a lottery.

Cannabis Business Opportunities

Medical Facility Conversion 

Existing medical cultivation, manufacturing, and dispensary facilities will be able to begin filing requests to convert to a comprehensive facility license beginning on December 8, 2022.  

To be considered for conversion, facilities must meet these requirements:

  • A plan to promote and encourage involvement in the regulated marijuana business by populations disproportionately impacted by marijuana prohibition.
  • A plan that describes how the licensee will serve both the medical and adult-use markets while maintaining adequate supply at reasonable pricing for qualifying patients.
  • $2,000 conversion fee.
  • Conversion requests must be made in an online manner authorized by the department.

There is a set of instructions accessible for anybody who would want to make a conversion request.

Cannabis License Types

In Missouri, there are various licenses that can be obtained to legally participate in the cannabis industry, such as:

A comprehensive cultivation facility license allows for the cultivation of marijuana for medical or recreational use at a designated facility.

A comprehensive dispensary facility license allows for the dispensing of marijuana products for medical or recreational use at a designated facility.

A comprehensive marijuana-infused products manufacturing facility license allows for the manufacturing of marijuana-infused products and pre-rolls for medical or recreational use at a designated facility.

A marijuana testing facility license allows for the testing of marijuana products at a designated testing facility.

Cannabis Business Fees

Here are the fees associated to opening a cannabis business in Missouri:

Fee Type

Annual Fee

Renewal Fee

Cultivation Facility



Dispensary Facility



Manufacturing Facility



Transportation Facility



Missouri is not currently accepting new applications for medical or comprehensive marijuana licenses. This is because current medical licenses can be converted into comprehensive licenses, which allow the sale of marijuana to both patients and the public. 

The department will announce when they will start accepting new applications and will give at least 6 months notice before the application period begins. The information on this section will be updated as it becomes available.

Discover the costs of opening a dispensary, including examples from various states, with this guide on the financial aspects of starting a dispensary.

Final Thoughts

There are a lot of events going on in Missouri that could change when and how recreational marijuana is legalized. We will keep you up to date on how to open a dispensary in Missouri and all the important news, including the news that isn’t so easy to find. You can sign up for our Missouri Cannabis Mailing List by filling out the form below.

This includes but is not limited to:

  • When will the new dispensary license application process in Missouri be available?
  • How much will it cost to open a dispensary in Missouri?
  • What are the requirements to open a dispensary in Missouri?
  • What special programs will be available?
  • And more

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